I have COMT and VDR mutations in addition to MTHFR mutations and because of this my body has excess methyl groups in my body already. Because I need the 5-methylfolate - I have to take that in methyl form but to balance it out - I need to take large doses of hydroxyb-12 other wise I run into symptoms of overmethylation and they are not fun.
COMT has been called the "warrior" or "worrier" gene based on the genotype. The wild-type COMT V158M genotype has been called the warrior genotype because there is a higher threshold of pressure to perform due to a lower baseline of dopamine. Stress slows down COMT, increasing dopamine and adrenaline levels.
For example, the COMT enzyme breaks down the catecholamine neurotransmitters (serotonin, dopamine, and norepinephrine). If a patient starts a high dose of methyl support and production of those neurotransmitters significantly increases, the COMT enzyme may not be able to keep up with the breakdown, leading to a state of catecholamine excess.
See full list on undermethylation.com
Mar 23, 2016 · According to the wikipedia entry for oxalobacter formigenes, “Quinolone, a broad-spectrum antibiotic, kills O. formigenes.If a person’s gastrointestinal (GI) tract lacks this bacterium, and therefore lacks the primary source for the oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some vitamin B6-modulated ...
COMT (Catechol-O-Methyltransferase) mutations affect the rate at which catecholamines are broken down. Catecholamines are: dopamine, norepinephrine, epinephrine, and catecholestrogens.
The most important enzymes in that cycle are MTHFR - that's probably the one that's best known; it stands for methylenetetrahydrofolate reductase - and then CBS, COMT, VDR, MTR, and MTRR are other genes that are involved in the methylation cycle. MTHFR Genes C677T and A1298C MTHFR genetic mutations affect methylation.
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